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This condition is caused by reduced blood flow to the leg, which can decrease mobility, physical performance and life quality

None of these have been validated in a published human randomized trial

"During the listing process for new listed medicines, sponsors can only choose from a list of permissible indications This list does not contain any indications referring to 'skin lightening' or 'skin whitening'," a spokesperson from the Department of Health said

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A safe prescribing decision also considers: eligibility and NHS pathway availability comorbidities and concurrent medicines tolerability and dose escalation patient preference and expectations capacity for follow-up and monitoring The difference between semaglutide and tirzepatide should therefore be framed as a clinical comparison, not a direct consumer recommendation